Drug interactions
Prednisolone + Typhoid vaccine live
Severity: Major
Prednisolone and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live attenuated typhoid vaccine (Ty21a) may cause invasive vaccine-strain infection in patients on immunosuppressive corticosteroids, and the response may be reduced.
What this interaction means in plain words
Prednisolone and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Glucocorticoid immunosuppression impairs control of live attenuated bacterial replication and blunts the immune response.
What to do
Use the inactivated injectable Vi polysaccharide vaccine instead in patients on immunosuppressive steroid doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Prednisolone with Typhoid vaccine live?
MediHelp rates the interaction as major. Prednisolone and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live attenuated typhoid vaccine (Ty21a) may cause invasive vaccine-strain infection in patients on immunosuppressive corticosteroids, and the response may be reduced.
How serious is the interaction between Prednisolone and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated injectable Vi polysaccharide vaccine instead in patients on immunosuppressive steroid doses.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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