Drug interactions
Promazine + Ramipril
Severity: Moderate
Promazine and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine with alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with ramipril, blood pressure lowering may be enhanced, especially at treatment initiation or in older patients.
What this interaction means in plain words
Promazine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from phenothiazine alpha-1 blockade and ACE inhibitor vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and lower the dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Promazine with Ramipril?
MediHelp rates the interaction as moderate. Promazine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine with alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with ramipril, blood pressure lowering may be enhanced, especially at treatment initiation or in older patients.
How serious is the interaction between Promazine and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and lower the dose if symptomatic hypotension occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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