Drug interactions
Promazine + Telavancin
Severity: Moderate
Promazine and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine antipsychotic that can prolong the QT interval, and telavancin may add to this effect. The combination increases the risk of ventricular arrhythmia including torsades de pointes.
What this interaction means in plain words
Promazine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation, with promazine blocking cardiac hERG potassium channels.
What to do
Check a baseline ECG and electrolytes and monitor the QTc during combined therapy. Consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Frequently asked questions
Can I take Promazine with Telavancin?
MediHelp rates the interaction as moderate. Promazine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine antipsychotic that can prolong the QT interval, and telavancin may add to this effect. The combination increases the risk of ventricular arrhythmia including torsades de pointes.
How serious is the interaction between Promazine and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc during combined therapy. Consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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