Drug interactions
Promethazine + Triazolam
Severity: Moderate
Promethazine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine and triazolam both depress the CNS, leading to enhanced sedation, impaired alertness and memory problems. Older patients are especially vulnerable to falls and confusion.
What this interaction means in plain words
Promethazine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via H1 antagonism and benzodiazepine GABA-A potentiation.
What to do
Use the lowest effective doses and avoid driving or hazardous activities. Reduce doses in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Promethazine with Triazolam?
MediHelp rates the interaction as moderate. Promethazine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine and triazolam both depress the CNS, leading to enhanced sedation, impaired alertness and memory problems. Older patients are especially vulnerable to falls and confusion.
How serious is the interaction between Promethazine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid driving or hazardous activities. Reduce doses in elderly patients.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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