Drug interactions
Promethazine + Yohimbine
Severity: Minor
Promethazine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is sedating while yohimbine is a stimulant that increases sympathetic activity, so the two may blunt each other's effects unpredictably. Yohimbine may also cause anxiety, hypertension and tachycardia, which could confound the use of promethazine.
What this interaction means in plain words
Promethazine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects; yohimbine alpha-2 antagonism versus promethazine sedation.
What to do
No routine action is needed beyond monitoring for reduced sedation and cardiovascular stimulation. Adjust doses according to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Promethazine with Yohimbine?
MediHelp rates the interaction as minor. Promethazine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine is sedating while yohimbine is a stimulant that increases sympathetic activity, so the two may blunt each other's effects unpredictably. Yohimbine may also cause anxiety, hypertension and tachycardia, which could confound the use of promethazine.
How serious is the interaction between Promethazine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed beyond monitoring for reduced sedation and cardiovascular stimulation. Adjust doses according to clinical response.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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