Drug interactions
Propantheline + Scopolamine
Severity: Moderate
Propantheline and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combining them adds to anticholinergic effects such as dry mouth, blurred vision, urinary retention, constipation, tachycardia and confusion. Older patients and those with glaucoma or prostatic enlargement are especially vulnerable.
What this interaction means in plain words
Propantheline and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antagonism at muscarinic acetylcholine receptors.
What to do
Avoid duplicate anticholinergic therapy where possible; if both are needed, use the lowest doses and monitor for urinary retention, constipation, tachycardia and delirium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propantheline and Scopolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Scopolamine
Frequently asked questions
Can I take Propantheline with Scopolamine?
MediHelp rates the interaction as moderate. Propantheline and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combining them adds to anticholinergic effects such as dry mouth, blurred vision, urinary retention, constipation, tachycardia and confusion. Older patients and those with glaucoma or prostatic enlargement are especially vulnerable.
How serious is the interaction between Propantheline and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate anticholinergic therapy where possible; if both are needed, use the lowest doses and monitor for urinary retention, constipation, tachycardia and delirium.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
