Drug interactions
Propantheline + Tolterodine
Severity: Moderate
Propantheline and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antimuscarinics, so combined use increases anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older adults are at higher risk of confusion.
What this interaction means in plain words
Propantheline and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid combining two antimuscarinics where possible. If both are needed, monitor for urinary retention, constipation and cognitive effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Propantheline with Tolterodine?
MediHelp rates the interaction as moderate. Propantheline and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antimuscarinics, so combined use increases anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older adults are at higher risk of confusion.
How serious is the interaction between Propantheline and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antimuscarinics where possible. If both are needed, monitor for urinary retention, constipation and cognitive effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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