Drug interactions
Propranolol + Salicylates
Severity: Minor
Propranolol and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, so any blunting of propranolol's antihypertensive effect is probably small. Higher doses over prolonged periods are more likely to matter.
What this interaction means in plain words
Propranolol and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Prostaglandin synthesis inhibition may cause mild fluid retention opposing the antihypertensive effect.
What to do
Monitor blood pressure if high-dose salicylates are used for an extended period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Salicylates?
MediHelp rates the interaction as minor. Propranolol and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, so any blunting of propranolol's antihypertensive effect is probably small. Higher doses over prolonged periods are more likely to matter.
How serious is the interaction between Propranolol and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if high-dose salicylates are used for an extended period.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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