Drug interactions
Propranolol + Sevelamer
Severity: Minor
Propranolol and Sevelamer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevelamer is a non-absorbed phosphate binder that could theoretically reduce oral propranolol absorption. No well-documented clinically significant interaction is established.
What this interaction means in plain words
Propranolol and Sevelamer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Sevelamer belongs to Miscellaneous.
Why it happens
Possible binding of propranolol in the gut reducing absorption; not well established.
What to do
Give propranolol at least 1 hour before or 3 hours after sevelamer. Monitor heart rate and blood pressure if doses cannot be separated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Sevelamer
- Carbamazepine + Sevelamer Moderate
- Ciprofloxacin + Sevelamer Moderate
- Dichlorphenamide + Sevelamer Moderate
- Erdafitinib + Sevelamer Moderate
- Gabapentin + Sevelamer Moderate
- Mycophenolic acid + Sevelamer Moderate
Frequently asked questions
Can I take Propranolol with Sevelamer?
MediHelp rates the interaction as minor. Propranolol and Sevelamer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sevelamer is a non-absorbed phosphate binder that could theoretically reduce oral propranolol absorption. No well-documented clinically significant interaction is established.
How serious is the interaction between Propranolol and Sevelamer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give propranolol at least 1 hour before or 3 hours after sevelamer. Monitor heart rate and blood pressure if doses cannot be separated.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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