Drug interactions
Propranolol + Sildenafil
Severity: Minor
Propranolol and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil causes mild systemic vasodilation, which may add to the blood pressure lowering of propranolol. Most patients tolerate the combination, but symptomatic hypotension or dizziness can occur.
What this interaction means in plain words
Propranolol and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive hypotensive effect from PDE5 inhibition-mediated vasodilation and beta-blockade.
What to do
Check blood pressure and counsel the patient about orthostatic symptoms when starting sildenafil. Begin with a low sildenafil dose if the patient is unstable on antihypertensives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Sildenafil?
MediHelp rates the interaction as minor. Propranolol and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sildenafil causes mild systemic vasodilation, which may add to the blood pressure lowering of propranolol. Most patients tolerate the combination, but symptomatic hypotension or dizziness can occur.
How serious is the interaction between Propranolol and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and counsel the patient about orthostatic symptoms when starting sildenafil. Begin with a low sildenafil dose if the patient is unstable on antihypertensives.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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