Drug interactions
Propranolol + Sodium citrate / citric acid
Severity: Minor
Propranolol and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral citrate-containing alkalinizing agents may modestly reduce the gastrointestinal absorption of propranolol. This could lessen its heart rate and blood pressure control, although the effect is probably small.
What this interaction means in plain words
Propranolol and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction of propranolol absorption in the gut; the mechanism is not well established.
What to do
Separate the oral doses by about 2 hours and monitor heart rate and blood pressure if control appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Propranolol and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral citrate-containing alkalinizing agents may modestly reduce the gastrointestinal absorption of propranolol. This could lessen its heart rate and blood pressure control, although the effect is probably small.
How serious is the interaction between Propranolol and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the oral doses by about 2 hours and monitor heart rate and blood pressure if control appears reduced.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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