Drug interactions
Propranolol + Terbutaline
Severity: Major
Propranolol and Terbutaline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a non-selective beta-blocker that blocks the bronchodilating effect of terbutaline and can provoke bronchospasm in patients with asthma or COPD. It may also leave unopposed effects on blood pressure in some patients.
What this interaction means in plain words
Propranolol and Terbutaline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propranolol belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Competitive antagonism of beta-2 adrenoceptors by propranolol opposes terbutaline's receptor agonism.
What to do
Avoid non-selective beta-blockers in patients who need terbutaline for reversible airway disease. If a beta-blocker is essential, use a cardioselective agent at the lowest dose and monitor respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Terbutaline
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Terbutaline?
MediHelp rates the interaction as major. Propranolol and Terbutaline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a non-selective beta-blocker that blocks the bronchodilating effect of terbutaline and can provoke bronchospasm in patients with asthma or COPD. It may also leave unopposed effects on blood pressure in some patients.
How serious is the interaction between Propranolol and Terbutaline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients who need terbutaline for reversible airway disease. If a beta-blocker is essential, use a cardioselective agent at the lowest dose and monitor respiratory status.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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