Drug interactions
Propranolol + Thiothixene
Severity: Moderate
Propranolol and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol and phenothiazine-type antipsychotics can increase each other's plasma levels, and thiothixene may add hypotension. This can lead to excess beta-blockade, orthostasis, and increased antipsychotic effects.
What this interaction means in plain words
Propranolol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable mutual inhibition of hepatic metabolism together with additive hypotensive effects.
What to do
Monitor blood pressure, heart rate, and antipsychotic adverse effects, and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Thiothixene?
MediHelp rates the interaction as moderate. Propranolol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol and phenothiazine-type antipsychotics can increase each other's plasma levels, and thiothixene may add hypotension. This can lead to excess beta-blockade, orthostasis, and increased antipsychotic effects.
How serious is the interaction between Propranolol and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, and antipsychotic adverse effects, and adjust doses as needed.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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