Drug interactions
Propranolol + Venlafaxine
Severity: Minor
Propranolol and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a weak CYP2D6 inhibitor and may slightly raise propranolol levels. Both agents can also affect blood pressure and heart rate, though the interaction is usually modest.
What this interaction means in plain words
Propranolol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6-mediated propranolol metabolism by venlafaxine.
What to do
Monitor heart rate and blood pressure when starting or adjusting venlafaxine. Reduce the propranolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Propranolol with Venlafaxine?
MediHelp rates the interaction as minor. Propranolol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Venlafaxine is a weak CYP2D6 inhibitor and may slightly raise propranolol levels. Both agents can also affect blood pressure and heart rate, though the interaction is usually modest.
How serious is the interaction between Propranolol and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting venlafaxine. Reduce the propranolol dose if bradycardia or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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