Drug interactions
Propranolol + Yohimbe
Severity: Moderate
Propranolol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises sympathetic outflow, blood pressure and heart rate. Propranolol may blunt the tachycardia but can leave alpha-mediated pressor effects, and yohimbe may reduce the antihypertensive effect of propranolol.
What this interaction means in plain words
Propranolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between alpha-2 antagonism with increased noradrenaline release and beta-blockade.
What to do
Advise patients to avoid yohimbe products. Monitor blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Yohimbe?
MediHelp rates the interaction as moderate. Propranolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises sympathetic outflow, blood pressure and heart rate. Propranolol may blunt the tachycardia but can leave alpha-mediated pressor effects, and yohimbe may reduce the antihypertensive effect of propranolol.
How serious is the interaction between Propranolol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products. Monitor blood pressure if used.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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