Drug interactions
Protriptyline + Quinine
Severity: Major
Protriptyline and Quinine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and tricyclic antidepressants carry arrhythmia risk in overdose or with other QT drugs. Together they raise the risk of ventricular arrhythmias.
What this interaction means in plain words
Protriptyline and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and conduction effects.
What to do
Avoid if feasible; otherwise obtain a baseline ECG and monitor QTc and electrolytes. Choose a non-QT-prolonging alternative where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Protriptyline with Quinine?
MediHelp rates the interaction as major. Protriptyline and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and tricyclic antidepressants carry arrhythmia risk in overdose or with other QT drugs. Together they raise the risk of ventricular arrhythmias.
How serious is the interaction between Protriptyline and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible; otherwise obtain a baseline ECG and monitor QTc and electrolytes. Choose a non-QT-prolonging alternative where possible.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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