Drug interactions
Protriptyline + Repaglinide
Severity: Minor
Protriptyline and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have been reported to alter glucose control, and some can enhance the effects of antidiabetic drugs. With repaglinide this may occasionally cause hypoglycemia, although the effect is inconsistent.
What this interaction means in plain words
Protriptyline and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effects on glucose homeostasis; the mechanism is not well established.
What to do
Monitor blood glucose when protriptyline is started or stopped. Adjust the repaglinide dose if glucose control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Protriptyline with Repaglinide?
MediHelp rates the interaction as minor. Protriptyline and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have been reported to alter glucose control, and some can enhance the effects of antidiabetic drugs. With repaglinide this may occasionally cause hypoglycemia, although the effect is inconsistent.
How serious is the interaction between Protriptyline and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when protriptyline is started or stopped. Adjust the repaglinide dose if glucose control changes.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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