Drug interactions
Pyrimethamine + Ropeginterferon alfa 2b
Severity: Moderate
Pyrimethamine and Ropeginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrimethamine is a folate antagonist that can suppress the bone marrow, and interferons can also cause cytopenias. Used together they may cause additive myelosuppression.
What this interaction means in plain words
Pyrimethamine and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression through pharmacodynamic effects.
What to do
Monitor complete blood counts regularly during the combination. Give folinic acid with pyrimethamine and reduce or stop either drug if marked cytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyrimethamine
- Deferiprone + Pyrimethamine Major
- Eliglustat + Pyrimethamine Major
- Acalabrutinib + Pyrimethamine Moderate
- Brexpiprazole + Pyrimethamine Moderate
- Dapsone + Pyrimethamine Moderate
- Folic acid + Pyrimethamine Moderate
Frequently asked questions
Can I take Pyrimethamine with Ropeginterferon alfa 2b?
MediHelp rates the interaction as moderate. Pyrimethamine and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine is a folate antagonist that can suppress the bone marrow, and interferons can also cause cytopenias. Used together they may cause additive myelosuppression.
How serious is the interaction between Pyrimethamine and Ropeginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly during the combination. Give folinic acid with pyrimethamine and reduce or stop either drug if marked cytopenia develops.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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