Drug interactions
Brexpiprazole + Pyrimethamine
Severity: Moderate
Brexpiprazole and Pyrimethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrimethamine may raise brexpiprazole exposure by inhibiting its CYP2D6 metabolism. Higher levels could increase sedation, akathisia, orthostatic hypotension and other adverse effects, especially if a CYP3A4 inhibitor is also given.
What this interaction means in plain words
Brexpiprazole and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2D6-mediated metabolism of brexpiprazole.
What to do
Monitor for adverse effects of brexpiprazole during co-use. Reduce the brexpiprazole dose to a quarter of usual if a strong or moderate CYP3A4 inhibitor is also given with a CYP2D6 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyrimethamine
- Deferiprone + Pyrimethamine Major
- Eliglustat + Pyrimethamine Major
- Acalabrutinib + Pyrimethamine Moderate
- Dapsone + Pyrimethamine Moderate
- Folic acid + Pyrimethamine Moderate
- Fosphenytoin + Pyrimethamine Moderate
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Pyrimethamine?
MediHelp rates the interaction as moderate. Brexpiprazole and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine may raise brexpiprazole exposure by inhibiting its CYP2D6 metabolism. Higher levels could increase sedation, akathisia, orthostatic hypotension and other adverse effects, especially if a CYP3A4 inhibitor is also given.
How serious is the interaction between Brexpiprazole and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of brexpiprazole during co-use. Reduce the brexpiprazole dose to a quarter of usual if a strong or moderate CYP3A4 inhibitor is also given with a CYP2D6 inhibitor.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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