Drug interactions
Quinapril + Sacubitril-valsartan
Severity: Contraindicated
Quinapril and Sacubitril-valsartan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking an ACE inhibitor with sacubitril/valsartan markedly increases the risk of angioedema, which may be life-threatening. The combination also adds to hypotension, hyperkalemia and renal effects.
What this interaction means in plain words
Quinapril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Combined ACE and neprilysin inhibition reduces bradykinin degradation, causing bradykinin-mediated angioedema.
What to do
Do not coadminister; separate quinapril and sacubitril/valsartan by at least 36 hours when switching in either direction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Quinapril with Sacubitril-valsartan?
MediHelp rates the interaction as contraindicated. Quinapril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Taking an ACE inhibitor with sacubitril/valsartan markedly increases the risk of angioedema, which may be life-threatening. The combination also adds to hypotension, hyperkalemia and renal effects.
How serious is the interaction between Quinapril and Sacubitril-valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; separate quinapril and sacubitril/valsartan by at least 36 hours when switching in either direction.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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