Drug interactions
Quinapril + Tolmetin
Severity: Moderate
Quinapril and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury and hyperkalemia. Risk is higher in older patients, those with volume depletion or existing renal impairment, and with concurrent diuretics.
What this interaction means in plain words
Quinapril and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, counteracting ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Quinapril with Tolmetin?
MediHelp rates the interaction as moderate. Quinapril and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury and hyperkalemia. Risk is higher in older patients, those with volume depletion or existing renal impairment, and with concurrent diuretics.
How serious is the interaction between Quinapril and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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