Drug interactions
Quinapril + Triamterene
Severity: Major
Quinapril and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone, and triamterene blocks distal potassium secretion, so together they can cause serious hyperkalemia. The risk is greater in renal impairment, diabetes, and older patients.
What this interaction means in plain words
Quinapril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive potassium retention from reduced aldosterone (ACE inhibition) and ENaC blockade.
What to do
Avoid unless hypokalemia is documented; if combined, check potassium and renal function within about a week and regularly thereafter.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Quinapril with Triamterene?
MediHelp rates the interaction as major. Quinapril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors reduce aldosterone, and triamterene blocks distal potassium secretion, so together they can cause serious hyperkalemia. The risk is greater in renal impairment, diabetes, and older patients.
How serious is the interaction between Quinapril and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless hypokalemia is documented; if combined, check potassium and renal function within about a week and regularly thereafter.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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