Drug interactions
Quinine + Telotristat ethyl
Severity: Moderate
Quinine and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may induce CYP3A4 and lower quinine concentrations. Reduced exposure could compromise treatment of malaria.
What this interaction means in plain words
Quinine and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 metabolism of quinine by telotristat.
What to do
Monitor clinical response and parasitological clearance when treating malaria. Consider an alternative antimalarial if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Quinine with Telotristat ethyl?
MediHelp rates the interaction as moderate. Quinine and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat may induce CYP3A4 and lower quinine concentrations. Reduced exposure could compromise treatment of malaria.
How serious is the interaction between Quinine and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and parasitological clearance when treating malaria. Consider an alternative antimalarial if efficacy appears reduced.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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