Drug interactions
Quinine + Tobramycin inhaled
Severity: Moderate
Quinine and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause ototoxicity, and aminoglycosides carry nephrotoxic risk. Systemic absorption from inhaled tobramycin is low, so the added risk is modest, but it may matter with renal impairment or high doses.
What this interaction means in plain words
Quinine and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic ototoxicity, with possible nephrotoxicity from absorbed tobramycin.
What to do
Monitor hearing symptoms and renal function, especially in renal impairment. Check serum tobramycin if systemic absorption is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Quinine with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Quinine and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause ototoxicity, and aminoglycosides carry nephrotoxic risk. Systemic absorption from inhaled tobramycin is low, so the added risk is modest, but it may matter with renal impairment or high doses.
How serious is the interaction between Quinine and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hearing symptoms and renal function, especially in renal impairment. Check serum tobramycin if systemic absorption is suspected.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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