Drug interactions
Quinupristin / dalfopristin + Siponimod
Severity: Moderate
Quinupristin / dalfopristin and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise siponimod concentrations. This may increase bradycardia and lymphopenia, particularly in patients with reduced CYP2C9 function.
What this interaction means in plain words
Quinupristin / dalfopristin and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces siponimod clearance.
What to do
Avoid in patients with CYP2C9*3 genotypes if possible. Otherwise monitor heart rate and lymphocyte counts during the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quinupristin / dalfopristin and Siponimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Quinupristin / dalfopristin with Siponimod?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise siponimod concentrations. This may increase bradycardia and lymphopenia, particularly in patients with reduced CYP2C9 function.
How serious is the interaction between Quinupristin / dalfopristin and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with CYP2C9*3 genotypes if possible. Otherwise monitor heart rate and lymphocyte counts during the antibiotic course.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
