Drug interactions
Quinupristin / dalfopristin + Tadalafil
Severity: Moderate
Quinupristin / dalfopristin and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise tadalafil concentrations. Greater exposure raises the risk of hypotension and other PDE5 inhibitor adverse effects.
What this interaction means in plain words
Quinupristin / dalfopristin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing tadalafil clearance.
What to do
Use the lowest effective tadalafil dose and monitor for hypotension, headache and priapism. Avoid in pulmonary arterial hypertension unless the dose can be monitored closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Quinupristin / dalfopristin with Tadalafil?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise tadalafil concentrations. Greater exposure raises the risk of hypotension and other PDE5 inhibitor adverse effects.
How serious is the interaction between Quinupristin / dalfopristin and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tadalafil dose and monitor for hypotension, headache and priapism. Avoid in pulmonary arterial hypertension unless the dose can be monitored closely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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