Drug interactions
Quinupristin / dalfopristin + Vincristine
Severity: Moderate
Quinupristin / dalfopristin and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase vincristine concentrations. This could increase neurotoxicity and gastrointestinal toxicity.
What this interaction means in plain words
Quinupristin / dalfopristin and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by quinupristin/dalfopristin reduces vincristine metabolism.
What to do
Consider an alternative antibiotic when feasible. If used, monitor for neuropathy, constipation and ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Quinupristin / dalfopristin with Vincristine?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase vincristine concentrations. This could increase neurotoxicity and gastrointestinal toxicity.
How serious is the interaction between Quinupristin / dalfopristin and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic when feasible. If used, monitor for neuropathy, constipation and ileus.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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