Drug interactions
Quinupristin / dalfopristin + Vinorelbine
Severity: Moderate
Quinupristin / dalfopristin and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise vinorelbine concentrations. This may increase neutropenia and neurotoxicity during the antibiotic course.
What this interaction means in plain words
Quinupristin / dalfopristin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated vinorelbine metabolism.
What to do
Monitor blood counts and neurotoxicity during co-administration. Use an alternative antibiotic if practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Quinupristin / dalfopristin with Vinorelbine?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise vinorelbine concentrations. This may increase neutropenia and neurotoxicity during the antibiotic course.
How serious is the interaction between Quinupristin / dalfopristin and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity during co-administration. Use an alternative antibiotic if practical.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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