Drug interactions
Rabeprazole + Rifabutin
Severity: Minor
Rabeprazole and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces drug-metabolizing enzymes and may lower rabeprazole exposure. Because rabeprazole is largely cleared non-enzymatically, the effect is likely modest.
What this interaction means in plain words
Rabeprazole and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4 and CYP2C19, increasing the metabolism of rabeprazole.
What to do
No routine adjustment is needed; assess symptom control and increase PPI dose if acid suppression is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rabeprazole with Rifabutin?
MediHelp rates the interaction as minor. Rabeprazole and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces drug-metabolizing enzymes and may lower rabeprazole exposure. Because rabeprazole is largely cleared non-enzymatically, the effect is likely modest.
How serious is the interaction between Rabeprazole and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; assess symptom control and increase PPI dose if acid suppression is inadequate.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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