Drug interactions
Rabeprazole + Sotorasib
Severity: Major
Rabeprazole and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility is pH dependent, and proton pump inhibitors reduce its exposure. This may lessen antitumor efficacy.
What this interaction means in plain words
Rabeprazole and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rabeprazole belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Elevated gastric pH reduces sotorasib dissolution and absorption.
What to do
Avoid PPIs and H2 antagonists where possible. If acid reduction is required, give sotorasib 4 hours before or 10 hours after a locally acting antacid.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rabeprazole and Sotorasib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Rabeprazole with Sotorasib?
MediHelp rates the interaction as major. Rabeprazole and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotorasib solubility is pH dependent, and proton pump inhibitors reduce its exposure. This may lessen antitumor efficacy.
How serious is the interaction between Rabeprazole and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs and H2 antagonists where possible. If acid reduction is required, give sotorasib 4 hours before or 10 hours after a locally acting antacid.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
