Drug interactions
Rabies vaccine chick embryo cell derived + Rituximab
Severity: Moderate
Rabies vaccine chick embryo cell derived and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab can blunt the antibody response to this inactivated rabies vaccine, leaving patients with inadequate protection. The consequences of failed protection against rabies are severe.
What this interaction means in plain words
Rabies vaccine chick embryo cell derived and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rituximab-mediated CD20-positive B-cell depletion impairs humoral vaccine responses.
What to do
Vaccinate before starting rituximab when possible, and verify neutralizing antibody titres afterward in patients on therapy. After any exposure, use complete post-exposure prophylaxis including immune globulin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Frequently asked questions
Can I take Rabies vaccine chick embryo cell derived with Rituximab?
MediHelp rates the interaction as moderate. Rabies vaccine chick embryo cell derived and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab can blunt the antibody response to this inactivated rabies vaccine, leaving patients with inadequate protection. The consequences of failed protection against rabies are severe.
How serious is the interaction between Rabies vaccine chick embryo cell derived and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting rituximab when possible, and verify neutralizing antibody titres afterward in patients on therapy. After any exposure, use complete post-exposure prophylaxis including immune globulin.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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