Drug interactions
Rabies vaccine chick embryo cell derived + Tocilizumab
Severity: Moderate
Rabies vaccine chick embryo cell derived and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab may reduce the antibody response to this inactivated rabies vaccine. The vaccine is non-live, so the concern is reduced protection rather than infection.
What this interaction means in plain words
Rabies vaccine chick embryo cell derived and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-6 receptor blockade attenuates antibody production after vaccination.
What to do
Vaccinate when indicated, especially after exposure, and measure neutralising antibody titres afterwards in patients on tocilizumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Rabies vaccine chick embryo cell derived with Tocilizumab?
MediHelp rates the interaction as moderate. Rabies vaccine chick embryo cell derived and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tocilizumab may reduce the antibody response to this inactivated rabies vaccine. The vaccine is non-live, so the concern is reduced protection rather than infection.
How serious is the interaction between Rabies vaccine chick embryo cell derived and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated, especially after exposure, and measure neutralising antibody titres afterwards in patients on tocilizumab.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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