Drug interactions
Raltegravir + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Raltegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral bowel preparations containing magnesium may bind raltegravir in the gut through polyvalent cation chelation. Reduced absorption could lower raltegravir exposure and risk virologic failure, particularly with repeated use.
What this interaction means in plain words
Raltegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium cations chelate raltegravir in the gastrointestinal tract, reducing absorption.
What to do
Take raltegravir at least 2 hours before the preparation, or delay it until after bowel cleansing is finished. Avoid aluminum or magnesium-containing products with raltegravir where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Raltegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Frequently asked questions
Can I take Raltegravir with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Raltegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral bowel preparations containing magnesium may bind raltegravir in the gut through polyvalent cation chelation. Reduced absorption could lower raltegravir exposure and risk virologic failure, particularly with repeated use.
How serious is the interaction between Raltegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take raltegravir at least 2 hours before the preparation, or delay it until after bowel cleansing is finished. Avoid aluminum or magnesium-containing products with raltegravir where feasible.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
