Drug interactions
Raltegravir + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Raltegravir and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This oral bowel preparation contains magnesium that may bind raltegravir in the gut. Lower absorption may reduce antiviral effect.
What this interaction means in plain words
Raltegravir and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium cations chelate raltegravir in the gastrointestinal tract, reducing absorption.
What to do
Give raltegravir at least 2 hours before the preparation, or after completion of bowel cleansing. Ensure the usual raltegravir dose is not missed on the preparation day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Frequently asked questions
Can I take Raltegravir with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Raltegravir and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This oral bowel preparation contains magnesium that may bind raltegravir in the gut. Lower absorption may reduce antiviral effect.
How serious is the interaction between Raltegravir and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give raltegravir at least 2 hours before the preparation, or after completion of bowel cleansing. Ensure the usual raltegravir dose is not missed on the preparation day.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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