Drug interactions
Ramipril + Salicylates
Severity: Moderate
Ramipril and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylsalicylic salicylates such as salsalate or choline salicylate may weaken the blood pressure effect of ramipril and affect renal function, similar to other NSAIDs. The effect is probably smaller than with potent NSAIDs and is most relevant in dehydration or kidney disease.
What this interaction means in plain words
Ramipril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces renal vasodilation and sodium excretion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium with regular or high-dose salicylate use, and keep patients well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Ramipril with Salicylates?
MediHelp rates the interaction as moderate. Ramipril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylsalicylic salicylates such as salsalate or choline salicylate may weaken the blood pressure effect of ramipril and affect renal function, similar to other NSAIDs. The effect is probably smaller than with potent NSAIDs and is most relevant in dehydration or kidney disease.
How serious is the interaction between Ramipril and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium with regular or high-dose salicylate use, and keep patients well hydrated.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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