Drug interactions
Ramipril + Salsalate
Severity: Moderate
Ramipril and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate that may modestly blunt ACE inhibitor antihypertensive effect and affect renal function. Its effect on renal prostaglandins is weaker than that of most NSAIDs.
What this interaction means in plain words
Ramipril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-related inhibition of renal prostaglandin synthesis can reduce renal perfusion and oppose ACE inhibitor effects.
What to do
Monitor blood pressure, creatinine and potassium, especially in older or dehydrated patients. Consider paracetamol if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Ramipril with Salsalate?
MediHelp rates the interaction as moderate. Ramipril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate that may modestly blunt ACE inhibitor antihypertensive effect and affect renal function. Its effect on renal prostaglandins is weaker than that of most NSAIDs.
How serious is the interaction between Ramipril and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, especially in older or dehydrated patients. Consider paracetamol if renal function worsens.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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