Drug interactions
Ramipril + Sodium citrate / citric acid
Severity: Minor
Ramipril and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium citrate is an alkalinizing agent that contributes a sodium load, which could slightly oppose the antihypertensive effect of ramipril. A meaningful clinical interaction is not well documented.
What this interaction means in plain words
Ramipril and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible sodium load opposing antihypertensive effect; no established pharmacokinetic mechanism.
What to do
Monitor blood pressure if sodium citrate is used regularly or in high doses, and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Ramipril with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Ramipril and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium citrate is an alkalinizing agent that contributes a sodium load, which could slightly oppose the antihypertensive effect of ramipril. A meaningful clinical interaction is not well documented.
How serious is the interaction between Ramipril and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if sodium citrate is used regularly or in high doses, and adjust antihypertensive therapy if needed.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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