Drug interactions
Ramipril + Synthetic human angiotensin ii
Severity: Moderate
Ramipril and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin II is used to raise blood pressure in vasodilatory shock. Patients on ACE inhibitors such as ramipril may have an exaggerated pressor response to angiotensin II because less endogenous angiotensin II is present, so blood pressure may rise more than expected.
What this interaction means in plain words
Ramipril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition lowers endogenous angiotensin II, which increases sensitivity to exogenous angiotensin II.
What to do
Start angiotensin II at the lowest dose and titrate to mean arterial pressure with continuous monitoring. Be aware that patients recently on an ACE inhibitor may need lower infusion rates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Ramipril with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Ramipril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin II is used to raise blood pressure in vasodilatory shock. Patients on ACE inhibitors such as ramipril may have an exaggerated pressor response to angiotensin II because less endogenous angiotensin II is present, so blood pressure may rise more than expected.
How serious is the interaction between Ramipril and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start angiotensin II at the lowest dose and titrate to mean arterial pressure with continuous monitoring. Be aware that patients recently on an ACE inhibitor may need lower infusion rates.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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