Drug interactions
Ramipril + Trifluoperazine
Severity: Moderate
Ramipril and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has some alpha-adrenergic blocking activity that can cause orthostatic hypotension. With ramipril, blood pressure lowering may be additive, particularly in older patients or at start of therapy.
What this interaction means in plain words
Ramipril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from phenothiazine alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms and reduce the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Ramipril with Trifluoperazine?
MediHelp rates the interaction as moderate. Ramipril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has some alpha-adrenergic blocking activity that can cause orthostatic hypotension. With ramipril, blood pressure lowering may be additive, particularly in older patients or at start of therapy.
How serious is the interaction between Ramipril and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms and reduce the dose of either drug if hypotension occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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