Drug interactions
Rapacuronium + Streptomycin
Severity: Major
Rapacuronium and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can impair neuromuscular transmission and enhance or prolong non-depolarizing blockade. This may cause prolonged paralysis and respiratory depression after surgery, and rapacuronium has been withdrawn from the market.
What this interaction means in plain words
Rapacuronium and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Aminoglycosides reduce presynaptic acetylcholine release and postsynaptic sensitivity, adding to non-depolarizing neuromuscular blockade.
What to do
Use an alternative neuromuscular blocker where possible, and monitor neuromuscular function with train-of-four with ventilatory support available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Rapacuronium with Streptomycin?
MediHelp rates the interaction as major. Rapacuronium and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides can impair neuromuscular transmission and enhance or prolong non-depolarizing blockade. This may cause prolonged paralysis and respiratory depression after surgery, and rapacuronium has been withdrawn from the market.
How serious is the interaction between Rapacuronium and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative neuromuscular blocker where possible, and monitor neuromuscular function with train-of-four with ventilatory support available.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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