Drug interactions
Rasagiline + Rifampin
Severity: Minor
Rasagiline and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a broad enzyme inducer with modest CYP1A2 effects and may reduce rasagiline exposure. The effect is likely small but could blunt rasagiline benefit.
What this interaction means in plain words
Rasagiline and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induces CYP1A2, increasing rasagiline clearance.
What to do
Monitor for loss of symptom control during rifampin therapy and after it is stopped. Adjust the rasagiline dose only if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Rifampin?
MediHelp rates the interaction as minor. Rasagiline and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin is a broad enzyme inducer with modest CYP1A2 effects and may reduce rasagiline exposure. The effect is likely small but could blunt rasagiline benefit.
How serious is the interaction between Rasagiline and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control during rifampin therapy and after it is stopped. Adjust the rasagiline dose only if clinically needed.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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