Drug interactions
Rasagiline + Selegiline transdermal
Severity: Contraindicated
Rasagiline and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are MAO inhibitors, and transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B. Together they cause excessive MAO inhibition, with risk of hypertensive crisis and serotonin toxicity.
What this interaction means in plain words
Rasagiline and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive inhibition of monoamine oxidase, causing loss of enzyme selectivity and accumulation of monoamines.
What to do
Do not use two MAO inhibitors together. Choose one agent and observe a washout of at least 14 days when switching.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Rasagiline and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are MAO inhibitors, and transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B. Together they cause excessive MAO inhibition, with risk of hypertensive crisis and serotonin toxicity.
How serious is the interaction between Rasagiline and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two MAO inhibitors together. Choose one agent and observe a washout of at least 14 days when switching.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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