Drug interactions
Rasagiline + Serdexmethylphenidate / dexmethylphenidate
Severity: Contraindicated
Rasagiline and Serdexmethylphenidate / dexmethylphenidate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product delivers dexmethylphenidate, and stimulants given with MAO inhibitors can cause hypertensive crisis. Labeling contraindicates use during and within 14 days of MAO inhibitor therapy.
What this interaction means in plain words
Rasagiline and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Increased synaptic catecholamines from dexmethylphenidate combine with MAO inhibition that prevents their breakdown.
What to do
Do not co-administer and allow 14 days after stopping the MAO inhibitor. Consider a non-stimulant ADHD medication.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as contraindicated. Rasagiline and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The combination product delivers dexmethylphenidate, and stimulants given with MAO inhibitors can cause hypertensive crisis. Labeling contraindicates use during and within 14 days of MAO inhibitor therapy.
How serious is the interaction between Rasagiline and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer and allow 14 days after stopping the MAO inhibitor. Consider a non-stimulant ADHD medication.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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