Drug interactions
Rasagiline + Somatropin
Severity: Minor
Rasagiline and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase the activity of some cytochrome P450 enzymes, which could speed the clearance of CYP1A2 substrates such as rasagiline. This could lower rasagiline exposure and reduce its effect on motor symptoms. Evidence is limited and the clinical significance is uncertain.
What this interaction means in plain words
Rasagiline and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rasagiline belongs to Central Nervous System; Somatropin belongs to Endocrine.
Why it happens
Somatropin may induce CYP450 activity including CYP1A2, increasing hepatic clearance of rasagiline.
What to do
Watch for loss of motor control in Parkinson's patients starting or stopping somatropin. Adjust the rasagiline dose only if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Rasagiline with Somatropin?
MediHelp rates the interaction as minor. Rasagiline and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase the activity of some cytochrome P450 enzymes, which could speed the clearance of CYP1A2 substrates such as rasagiline. This could lower rasagiline exposure and reduce its effect on motor symptoms. Evidence is limited and the clinical significance is uncertain.
How serious is the interaction between Rasagiline and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for loss of motor control in Parkinson's patients starting or stopping somatropin. Adjust the rasagiline dose only if symptoms worsen.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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