Drug interactions
Rasagiline + Sufentanil sl
Severity: Major
Rasagiline and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids in patients on MAO inhibitors may cause respiratory depression, coma, hypotension or serotonin syndrome. Labeling for sublingual sufentanil advises against use with MAO inhibitors or within 14 days of stopping them.
What this interaction means in plain words
Rasagiline and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with possible serotonergic toxicity or altered opioid effect from MAO inhibition.
What to do
Avoid unless no alternative exists. If urgent opioid therapy is needed, use small titrated doses and monitor blood pressure, respiratory rate and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Sufentanil sl?
MediHelp rates the interaction as major. Rasagiline and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids in patients on MAO inhibitors may cause respiratory depression, coma, hypotension or serotonin syndrome. Labeling for sublingual sufentanil advises against use with MAO inhibitors or within 14 days of stopping them.
How serious is the interaction between Rasagiline and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless no alternative exists. If urgent opioid therapy is needed, use small titrated doses and monitor blood pressure, respiratory rate and mental status.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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