Drug interactions
Rasagiline + Sumatriptan intranasal
Severity: Moderate
Rasagiline and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is a 5-HT1B/1D agonist that is metabolized by MAO-A, and concurrent MAO inhibition may raise its exposure. Serotonin syndrome has been reported with triptans in combination with serotonergic drugs. Rasagiline is selective for MAO-B, so the risk is lower than with nonselective MAOIs.
What this interaction means in plain words
Rasagiline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with possible reduced sumatriptan metabolism if MAO-A selectivity is lost.
What to do
Monitor for serotonin syndrome symptoms and keep rasagiline within its labeled dose. Use the lowest effective sumatriptan dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Rasagiline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is a 5-HT1B/1D agonist that is metabolized by MAO-A, and concurrent MAO inhibition may raise its exposure. Serotonin syndrome has been reported with triptans in combination with serotonergic drugs. Rasagiline is selective for MAO-B, so the risk is lower than with nonselective MAOIs.
How serious is the interaction between Rasagiline and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms and keep rasagiline within its labeled dose. Use the lowest effective sumatriptan dose.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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