Drug interactions
Rasagiline + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Rasagiline and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2 agonist, and labeling advises extreme caution with MAO inhibitors because cardiovascular effects may be potentiated. This can cause tachycardia, palpitations and blood pressure rises, though inhaled systemic exposure is low.
What this interaction means in plain words
Rasagiline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may enhance the sympathomimetic cardiovascular effects of systemically absorbed beta2 agonist.
What to do
Monitor heart rate, blood pressure and ECG or symptoms of arrhythmia when used together. Consider an alternative bronchodilator if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rasagiline and Umeclidinium bromide / vilanterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Rasagiline and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta2 agonist, and labeling advises extreme caution with MAO inhibitors because cardiovascular effects may be potentiated. This can cause tachycardia, palpitations and blood pressure rises, though inhaled systemic exposure is low.
How serious is the interaction between Rasagiline and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG or symptoms of arrhythmia when used together. Consider an alternative bronchodilator if cardiovascular effects occur.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
