Drug interactions
Rasagiline + Yohimbine
Severity: Major
Rasagiline and Yohimbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha2 antagonist that increases noradrenergic outflow and blood pressure. With an MAO inhibitor, hypertensive episodes and tachycardia may be exaggerated.
What this interaction means in plain words
Rasagiline and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Alpha2-adrenoceptor blockade increases norepinephrine release while MAO inhibition reduces its breakdown, giving additive pressor effects.
What to do
Avoid yohimbine during rasagiline therapy and for about 2 weeks after stopping an MAO inhibitor. Monitor blood pressure if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Yohimbine?
MediHelp rates the interaction as major. Rasagiline and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine is an alpha2 antagonist that increases noradrenergic outflow and blood pressure. With an MAO inhibitor, hypertensive episodes and tachycardia may be exaggerated.
How serious is the interaction between Rasagiline and Yohimbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine during rasagiline therapy and for about 2 weeks after stopping an MAO inhibitor. Monitor blood pressure if exposure occurs.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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