Drug interactions
Regadenoson + Theophylline
Severity: Major
Regadenoson and Theophylline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Theophylline blocks adenosine receptors, which can blunt the vasodilator action of regadenoson during pharmacologic stress imaging. This may lead to a false-negative or non-diagnostic test.
What this interaction means in plain words
Regadenoson and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Regadenoson belongs to Cardiovascular; Theophylline belongs to Respiratory.
Why it happens
Theophylline is a competitive adenosine receptor antagonist and opposes regadenoson's A2A agonism.
What to do
Withhold theophylline for at least 12 hours before regadenoson; if the stress test is needed sooner, consider an alternative stress method.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Regadenoson - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Regadenoson
- Dipyridamole + Regadenoson Major
- Caffeine + Regadenoson Moderate
Frequently asked questions
Can I take Regadenoson with Theophylline?
MediHelp rates the interaction as major. Regadenoson and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Theophylline blocks adenosine receptors, which can blunt the vasodilator action of regadenoson during pharmacologic stress imaging. This may lead to a false-negative or non-diagnostic test.
How serious is the interaction between Regadenoson and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold theophylline for at least 12 hours before regadenoson; if the stress test is needed sooner, consider an alternative stress method.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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