Drug interactions
Caffeine + Regadenoson
Severity: Moderate
Caffeine and Regadenoson: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine and other methylxanthines block adenosine receptors, which is how regadenoson produces coronary vasodilation. Recent caffeine intake can blunt the vasodilator response and lead to a false-negative or less reliable myocardial perfusion stress test.
What this interaction means in plain words
Caffeine and Regadenoson can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Regadenoson belongs to Cardiovascular.
Why it happens
Competitive antagonism of adenosine A2A receptors by caffeine opposing the agonist action of regadenoson.
What to do
Withhold caffeine and other methylxanthines (coffee, tea, cola, theophylline) for at least 12 hours before the stress test, or per local protocol. Reschedule the test if recent intake is confirmed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Other interactions of Regadenoson
Frequently asked questions
Can I take Caffeine with Regadenoson?
MediHelp rates the interaction as moderate. Caffeine and Regadenoson can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Caffeine and other methylxanthines block adenosine receptors, which is how regadenoson produces coronary vasodilation. Recent caffeine intake can blunt the vasodilator response and lead to a false-negative or less reliable myocardial perfusion stress test.
How serious is the interaction between Caffeine and Regadenoson?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold caffeine and other methylxanthines (coffee, tea, cola, theophylline) for at least 12 hours before the stress test, or per local protocol. Reschedule the test if recent intake is confirmed.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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